N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE
ZM 447439
CAS: 331771-20-1
Molecular Formula: C29H31N5O4
N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE - Names and Identifiers
N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE - Physico-chemical Properties
| Molecular Formula | C29H31N5O4 |
| Molar Mass | 513.59 |
| Melting Point | 117-120°C |
| Solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). |
| Appearance | White solid |
| Color | White |
| Storage Condition | Desiccate at RT |
| Stability | Stable for 1 year from date of purchase? as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | In vitro, ZM-447439 selectively inhibited recombinant human Aurora A and B with IC50 of 110 and 130 nM, respectively, while inhibiting other different structural types of protein kinases, including the mitotic kinases CDK1 and PLK1, IC50>10 μm. The Aurora kinase inhibitor, ZM-447439, inhibited the growth of three types of cell lines, I .e., BON, QGP-1, and MIP-101, for 72 hours with an IC50 of 3 μm, 0.9 μm, and 3 μm, respectively, this effect was time-and dose-dependent. In addition, ZM-447439 effectively induced apoptosis by promoting DNA division and caspase 3 and 7 activation, and GEP-NET cells were arrested in G0/G1 and G2/M phases. In mouse embryos, ZM-447439 inhibition of Aurora kinase, by regulating the G2 to metaphase histone H3 serine 10 (H3S10Ph) with different perturbations at each embryo cycle, leads to abnormalities in the first two divisions. The latest research shows that ZM-447439 acts on cervical cancer SiHa cells, inhibits growth and apoptosis, and enhances the chemical sensitivity to Cisplatin. In vitro, ZM-447439 selectively inhibited recombinant human Aurora A and B with IC50 of 110 and 130 nM, respectively, while inhibiting other different structural types of protein kinases, including the mitotic kinases CDK1 and PLK1, IC50>10 μm. The Aurora kinase inhibitor, ZM-447439, inhibited the growth of three types of cell lines, I .e., BON, QGP-1, and MIP-101, for 72 hours with an IC50 of 3 μm, 0.9 μm, and 3 μm, respectively, this effect was time-and dose-dependent. In addition, ZM-447439 effectively induces apoptosis by promoting DNA division and caspase 3 and 7 activation, and causes GEP-NET cells to pause in G0/G1 and G2/M phases. In mouse embryos, ZM-447439 inhibition of Aurora kinase, by regulating the G2 to metaphase histone H3 serine 10 (H3S10Ph) with different perturbations at each embryo cycle, leads to abnormalities in the first two divisions. The latest research shows that ZM-447439 acts on cervical cancer SiHa cells, inhibits growth and apoptosis, and enhances the chemical sensitivity to Cisplatin. |
N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.947 ml | 9.735 ml | 19.471 ml |
| 5 mM | 0.389 ml | 1.947 ml | 3.894 ml |
| 10 mM | 0.195 ml | 0.974 ml | 1.947 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.389 ml |
Last Update：2024-01-02 23:10:35
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CAS: 331771-20-1
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Product Name: ZM 447439 Request for quotation
CAS: 331771-20-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 331771-20-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: ZM 447439 Visit Supplier Webpage Request for quotation
CAS: 331771-20-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 331771-20-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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